My guess is that meditation will be fine on most of these medications. Who knows, maybe even better! But it is possible that Klonopin and Vicodin may make you too sedated to do certain types of meditation. And, since they interfere with deep structure sleep, you may be too tired to do an "awakening" type meditation. By the way, are you sure that you are have been prescribed a short-acting narcotic (Vicodin) for restless leg syndrome? I've never heard of Vicodin (or any other narcotic) prescribed for RLS. Just curious. Good luck. Jim
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