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Unread May 11th, 2009, 11:33 PM
ToddStark ToddStark is offline
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Posts: 174
Post Re: Badcock: A New Split Brain

The "Mouse Trap" blog on cognitive and developmental psychology had a recent commentary about a Nature article possibly relevant to the Badcock-Crespi theory.


There is a recent article in Nature Neuroscience by Philpot et al regarding how experience-dependent synaptic plasticity is downregulated in Angelmans' syndrome and perhaps in Autism too, as the Ube3a gene involved is implicated in both disorders.

First a little history about Angelman- it is a disorder caused by deletion/lack of a maternally imprinted UBE3a gene in chromosomal region 15q11-q13 . It is typically contrasted with Prader-Willi syndrome which is caused by a paternally imprinted gene malfunction in the same chromosomal region. Christopher Badcock has used this to contrast Autism (related to Angelman) and Psychosis (more common in PWS) to argue that Autism and Psychosis are due to a genomic imprinting tug of war between fathers and mothers genes.

I have written about Badcock's and Crespi's thesis before and how it fits in with my views on Autism and Psychosis; suffice it to say that I am seeing the new study primarily from this prism of Autism and Psychosis dichotomy.


Nature Neuroscience article by Philpot et. al. [PDF]: http://www.nature.com/neuro/journal/...df/nn.2327.pdf

Mouse Trap Blog commentary: http://the-mouse-trap.blogspot.com/2...utism-and.html
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