Neurobiology of SSRI's

I am doing a bit of research on the molecular defects underlyng OCD. I have a few questions which you may be able to help me with.
First off, I am wondering during the neural impulse pathway, what causes the release of serotonin into the synaptic cleft? Better stated, I know there are many chemicals/neurotransmitters being transmitted, is there a specific set of neurons which possess high concentrations of serotonin? If not, it would come to my understanding that most or all neurons contain a myriad of neurotransmitters, so my question is, what signal (ie: particular frequency of NA, K ion channel openings) causes the release of serotonin into the synaptic cleft, and is calcium somewhat involved at the cellular level?
Finally I am wondering how OCD symptoms are derived from the molecular level? For example symptoms of a haemophilliac are apparent and can be traced down to the genetics of an individual, can anyone replicate a similar model of OCD starting at the molecular/serotonin level to the overt symptomatic behaviour of an individual such as obsessions?
Thanks for your time!

Replies:

Re: Neurobiology of SSRI's, by Steven Locke, 7/4/99 OCD and the biological myth, by Paul Salkovskis, 7/4/99 Re: Neurobiology of SSRI's, by John Martin, 7/7/99 Re: Neurobiology of SSRI's, by Paul Salkovskis, 7/8/99 Re: Neurobiology of SSRI's, by John Martin, 7/8/99 Re: Neurobiology of SSRI's, by Paul Salkovskis, 7/9/99 Re: Neurobiology of SSRI's, by John Martin, 7/9/99 Re: Neurobiology of SSRI's, by Paul Salkovskis, 7/9/99 Re: Neurobiology of SSRI's, by John Martin, 7/9/99 twins, ocd, stuff, by Paul Salkovskis, 7/10/99 How do you most effectively explain such issues to patients?, by Troy Raffield, 8/6/99 Re: How do you most effectively explain such issues to patients?, by Darra J Murphy, 5/22/00 Re: How do you most effectively explain such issues to patients?, by Troy Raffield, 06/29/00 Re: How do you most effectively explain such issues to patients?, by Troy Raffield, 08/28/00 Re: How Can They Treat It When They Can't Measure It?, by Bonnie, 10/24/03 Re:How do you most effectively explain such issues to patients?, by , 12/21/00 Re: Neurobiology of SSRI's, by Dr. Mike, 10/12/99 Neurobiology of SSRI's and brain disease, by Paul Salkovskis, 10/19/99 Re:Neurobiology of SSRI's and brain disease, by Brewnetty Angelfire, Cognitive Retraining student, 12/08/00 Re: Neurobiology of SSRI's, by Simon Sobo, M.D, 03/06/02

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